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MSC 2032964A

CAS No. 1124381-43-6

MSC 2032964A( MSC-2032964A | MSC2032964A | MSC 2032964A )

Catalog No. M27999 CAS No. 1124381-43-6

MSC 2032964A is a potent selective ASK1 inhibitor (IC50 = 93 nM) that is oral bioavailable and brain permeable. It inhibited neuroinflammation in mouse EAE models and blocked LPS-induced phosphorylation of ASK1 and p38 in cultured mouse astrocytes.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    MSC 2032964A
  • Note
    Research use only, not for human use.
  • Brief Description
    MSC 2032964A is a potent selective ASK1 inhibitor (IC50 = 93 nM) that is oral bioavailable and brain permeable. It inhibited neuroinflammation in mouse EAE models and blocked LPS-induced phosphorylation of ASK1 and p38 in cultured mouse astrocytes.
  • Description
    MSC 2032964A is a potent selective ASK1 inhibitor (IC50 = 93 nM) that is oral bioavailable and brain permeable. It inhibited neuroinflammation in mouse EAE models and blocked LPS-induced phosphorylation of ASK1 and p38 in cultured mouse astrocytes.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    MSC-2032964A | MSC2032964A | MSC 2032964A
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    Calcium Channel
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1124381-43-6
  • Formula Weight
    362.316
  • Molecular Formula
    C16H13F3N6O
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    FC(F)(F)c1cc(NC2CC2)n2nc(NC(=O)c3cccnc3)nc2c1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Samy MEROUEH, et al. Preparation of pyrazolyl acylpyrazolines for the treatment of pain. WO2020061303A1
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